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Stoke Therapeutics, Inc.

Stage 4 · Declining · week 6

As of Oct 22, 2026, Stoke Therapeutics is in Stage 4, the downtrend phase, now in week 6 (since Sep 17, 2026). It closed at $25.70, 33.0% below its 52-week high and below its 200-day average, which is falling.

Stoke Therapeutics, Inc. engages in the development of treatments for severe genetic diseases by upregulating protein expression. More about the company

$25.70
+0.08% today
$1.7B · Small cap
Market Neutral — Building

Pro read

Pro

Our read

Declining, below its long-term trend

Setup score

—

Momentum

Steady

Edge

—

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Stage Cycle Timeline2023-08-16 → 2026-10-22
S4 17w
S1 14w
S2 21w
S4 24w
S2 44w
2023-08-162026-10-22
S1S2S3S4Setup score (0–10, dashed line at 5)
S3 1w → S4 17w → S1 14w → S2 21w → S3 4w → S2 2w → S3 8w → S4 24w → S1 8w → S2 44w → S3 7w → S4 6w → S1 4w → S4 5w current
Total tracked: 166 weeks across 14 stage runs.

STOK among Biotechnology266th of 591 by relative strength

All 591 →
Stocks in Biotechnology ranked by relative strength, with stage and one-month change
#StockStageRS1M
1GTBPStage 2 · wk 799−22.3%
2IOVAStage 2 · wk 1899+38.8%
3SLSStage 3 · wk 499−1.5%
4MRNAStage 2 · wk 1799+11.3%
5TWSTStage 2 · wk 3999−14.5%
6KODStage 2 · wk 499+172.1%
7ERASStage 3 · wk 599+0.7%
8CLYMStage 3 · wk 399−15.8%
…266STOKStage 4 · wk 636−1.6%
vs 52W High
-33.0%
$22.37 lo$38.35 hi
33.0% below 52W high, ongoing decline
In Stage 4, distance from the 52-week high reflects an ongoing decline, not a discount.
Stage Maturity
Week 6
1w13w26w
Week 6, early Stage 4 decline
How long this stock has been in Stage 4 decline. The longer the downtrend, the more entrenched the selling pressure. No length of decline marks a bottom on its own.
vs 200 DMA
-17.4%
200 DMA: $31.10 · sloping down
In Stage 4, the stock is below its 200-day average, the hallmark of a downtrend. Stage analysis waits for that to reverse before buying.
Rel Volume
1.44x
vs 50-day avg
High volume on down days in Stage 4 confirms institutional selling. Low-volume bounces are typical. They lack real buyers and are easy to mistake for reversals.
Trend Health
↓
Short-term trend rolling over
Two reads of momentum. The arrow shows the direction of the short-term trend: rising (↑ or ↗), flat (→) or rolling over (↓). The ⇈ mark appears when our trend model reads the move as gaining speed on top of the longer trend. Strongest when both agree.
1M
-1.6%
3M
-12.3%
6M
-26.4%
YTD
-16.8%
1Y
-25.9%
Scan Membership
Breakout Watch
Latest: 2024-09-18
4 appearances in last 60 days. First seen: 2020-07-13.
A stock that keeps qualifying week after week does so because its Stage 2 structure keeps holding. Staying power in the scan says more about the trend than any single appearance.
Recent Stage Timeline
2026-10-22S4
Wk 6 · Vol 1.44x
2026-10-21S4
Wk 5 · Vol 1.93x
2026-10-20S4
Wk 5 · Vol 2.78x
2026-10-19S4
Wk 5 · Vol 0.80x
2026-10-16S4
Wk 5 · Vol 1.00x
2026-10-15S4
Wk 5 · Vol 0.93x
2026-10-14S4
Wk 4 · Vol 1.23x
2026-10-13S4
Wk 4 · Vol 0.66x
2026-10-12S4
Wk 4 · Vol 0.40x
2026-10-09S4
Wk 4 · Vol 0.98x
2026-10-08S4
Wk 4 · Vol 0.74x
2026-10-07S4
Wk 3 · Vol 0.68x
Moving averages & range
50 DMA
$28.14
200 DMA
$31.10
52W High
$38.35
52W Low
$22.37
5D Low
$24.17
Resistance levels (recent highs)
20d High
$26.61
60d High
$33.46
120d High
$34.18
250d High
$38.35
Next resistance
+3.5%
to 20d High
ROE
-61.1%
Profit margin 0.0%
Dividend Yield
0.00%
P/B 4.6

Stoke Therapeutics: quick answers

What stage is Stoke Therapeutics in?

As of Oct 22, 2026, Stoke Therapeutics (STOK) is in Stage 4, the downtrend phase. It entered Stage 4 on Sep 17, 2026 and is in week 6. What the four stages mean

Is Stoke Therapeutics in an uptrend?

No. Stoke Therapeutics is in a Stage 4 downtrend. It trades 17.4% below its 200-day average, which is falling.

How far is Stoke Therapeutics from its 52-week high?

Stoke Therapeutics closed at $25.70 on Oct 22, 2026, 33.0% below its 52-week high of $38.35. Its 52-week low is $22.37.

How has Stoke Therapeutics performed over the past year?

As of Oct 22, 2026, Stoke Therapeutics is down 25.9% over the past year and down 16.8% so far in 2026.

Which sector and industry is Stoke Therapeutics in?

Stoke Therapeutics is in the Biotechnology industry, part of the Health Care sector.

About this companyHealth Care· Biotechnology

Stoke Therapeutics, Inc. engages in the development of treatments for severe genetic diseases by upregulating protein expression. The company utilizes its proprietary Targeted Augmentation of Nuclear Gene Output (TANGO) approach in developing antisense oligonucleotides (ASOs) to selectively restore protein levels. Its lead product candidates include STK-002, which is in Phase 1 clinical trials for the treatment of autosomal dominant optic atrophy; and Zorevunersen (STK-001), an investigational new medicine for the treatment of Dravet syndrome is being evaluated in phase 3 clinical trials. The company also develops programs focused on various targets, including haploinsufficiency diseases of the central nervous system and eye. It has a license and collaboration with Biogen Inc. for the development and commercialization of zorevunersen medicine for the treatment of Dravet syndrome; and Acadia Pharmaceuticals Inc. for the discovery, development, and commercialization of novel RNA-based medicines for the treatment of genetic neurodevelopmental diseases. The company was formerly known as ASOthera Pharmaceuticals, Inc. and changed its name to Stoke Therapeutics, Inc. in May 2016. Stoke Therapeutics, Inc. was incorporated in 2014 and is headquartered in Bedford, Massachusetts.

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All analytics based on EOD data. Data as of 2026-10-22. Past data patterns are not indicative of future results. This page is a data analytics tool only.