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Septerna, Inc.

Stage 2 · Advancing · week 20

As of Oct 22, 2026, Septerna is in Stage 2, the uptrend phase, now in week 20 (since Jun 3, 2026). It closed at $40.88, 15.2% below its 52-week high and above its 200-day average, which is rising.

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflamm… More about the company

$40.88
+0.29% today
$1.9B · Small cap
Market Neutral — Building

Pro read

Pro

Our read

In Stage 2, but it has already run

Setup score

—

Momentum

Steady

Edge

—

Setup-score rank among Stage 2 peers: #1 of 110 in Biotechnology · #1 of 272 in Health Care

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Loading price chart…
Stage Cycle Timeline2024-10-25 → 2026-10-22
S? 42w
S2 28w
S3 10w
S2 20w
2024-10-252026-10-22
S1S2S3S4Setup score (0–10, dashed line at 5)
S? 42w → S1 4w → S2 28w → S3 10w → S2 20w current
Total tracked: 104 weeks across 5 stage runs.

SEPN among Biotechnology54th of 591 by relative strength

All 591 →
Stocks in Biotechnology ranked by relative strength, with stage and one-month change
#StockStageRS1M
1GTBPStage 2 · wk 799−22.3%
2IOVAStage 2 · wk 1899+38.8%
3SLSStage 3 · wk 499−1.5%
4MRNAStage 2 · wk 1799+11.3%
5TWSTStage 2 · wk 3999−14.5%
6KODStage 2 · wk 499+172.1%
7ERASStage 3 · wk 599+0.7%
8CLYMStage 3 · wk 399−15.8%
…54SEPNStage 2 · wk 2094+6.3%
vs 52W High
-15.2%
$18.10 lo$48.19 hi
15.2% below 52W high, deeper pullback
How far this stock is from its 52-week high. A pullback of 3–20% while Stage 2 structure holds is typically a better entry than chasing near the high.
Stage Maturity
Week 20
1w13w26w
Week 20, proven structure
How long this stock has been in Stage 2. The sweet spot is mid-run: long enough to prove the structure holds, not so long that it's extended. Very fresh moves (weeks 1–4) often need more time to confirm.
vs 200 DMA
29.5%
200 DMA: $31.56 · rising
Long-term trend anchor. When the stock and the S&P 500 are both above their 200-day averages, the backdrop supports continuation.
Rel Volume
0.62x
vs 50-day avg
Low vol (0.5–1x) on pullbacks = resting, not being sold. High vol on breakouts = commitment. Volume spike on down days is a warning sign.
Trend Health
↓
Short-term trend rolling over
Two reads of momentum. The arrow shows the direction of the short-term trend: rising (↑ or ↗), flat (→) or rolling over (↓). The ⇈ mark appears when our trend model reads the move as gaining speed on top of the longer trend. Strongest when both agree.
1M
+6.3%
3M
+23.5%
6M
+63.7%
YTD
+46.1%
1Y
+91.8%
Scan Membership
Not in any current scan.
Recent Stage Timeline
2026-10-22S2
Wk 20 · Vol 0.62x
2026-10-21S2
Wk 20 · Vol 0.58x
2026-10-20S2
Wk 20 · Vol 1.00x
2026-10-19S2
Wk 20 · Vol 0.98x
2026-10-16S2
Wk 19 · Vol 0.56x
2026-10-15S2
Wk 19 · Vol 0.65x
2026-10-14S2
Wk 19 · Vol 0.88x
2026-10-13S2
Wk 19 · Vol 1.19x
2026-10-12S2
Wk 19 · Vol 0.50x
2026-10-09S2
Wk 18 · Vol 0.84x
2026-10-08S2
Wk 18 · Vol 1.85x
2026-10-07S2
Wk 18 · Vol 2.66x
Moving averages & range
50 DMA
$39.01
200 DMA
$31.56
52W High
$48.19
52W Low
$18.10
5D Low
$36.35
Resistance levels (recent highs)
20d High
$40.88
60d High
$48.19
120d High
$48.19
250d High
$48.19
Next resistance
+17.9%
to 60d High
ROE
-6.3%
Profit margin -24.5%
Dividend Yield
0.00%
P/B 4.8

Septerna: quick answers

What stage is Septerna in?

As of Oct 22, 2026, Septerna (SEPN) is in Stage 2, the uptrend phase. It entered Stage 2 on Jun 3, 2026 and is in week 20. What the four stages mean

Is Septerna in an uptrend?

Yes. Septerna is in a Stage 2 uptrend. It trades 29.5% above its 200-day average, which is rising.

How far is Septerna from its 52-week high?

Septerna closed at $40.88 on Oct 22, 2026, 15.2% below its 52-week high of $48.19. Its 52-week low is $18.10.

How has Septerna performed over the past year?

As of Oct 22, 2026, Septerna is up 91.8% over the past year and up 46.1% so far in 2026.

Which sector and industry is Septerna in?

Septerna is in the Biotechnology industry, part of the Health Care sector.

About this companyHealth Care· Biotechnology

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women's health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

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All analytics based on EOD data. Data as of 2026-10-22. Past data patterns are not indicative of future results. This page is a data analytics tool only.