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Praxis Precision Medicines, Inc.

Stage 4 · Declining · week 1⚠ 3→4 today

As of Oct 22, 2026, Praxis Precision Medicines is in Stage 4, the downtrend phase, now in its first week (since Oct 22, 2026). It closed at $258.92, 33.0% below its 52-week high and below its 200-day average, which is falling.

Praxis Precision Medicines, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-in… More about the company

$258.92
+0.96% today
$7.2B · Mid cap
Market Neutral — Building

Pro read

Pro

Our read

Declining, below its long-term trend

Setup score

—

Momentum

Steady

Edge

—

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Stage Cycle Timeline2023-08-16 → 2026-10-22
S2 20w
S2 31w
S1 15w
S2 35w
2023-08-162026-10-22
S1S2S3S4Setup score (0–10, dashed line at 5)
S4 1w → S1 12w → S4 4w → S3 1w → S4 2w → S3 1w → S2 20w → S3 9w → S2 31w → S3 3w → S4 10w → S1 15w → S4 4w → S1 1w → S2 35w → S3 9w → S2 6w → S3 3w → S4 1w current
Total tracked: 165 weeks across 19 stage runs.

PRAX among Biotechnology111th of 591 by relative strength

All 591 →
Stocks in Biotechnology ranked by relative strength, with stage and one-month change
#StockStageRS1M
1GTBPStage 2 · wk 799−22.3%
2IOVAStage 2 · wk 1899+38.8%
3SLSStage 3 · wk 499−1.5%
4MRNAStage 2 · wk 1799+11.3%
5TWSTStage 2 · wk 3999−14.5%
6KODStage 2 · wk 499+172.1%
7ERASStage 3 · wk 599+0.7%
8CLYMStage 3 · wk 399−15.8%
…111PRAXStage 4 · wk 180−8.2%
vs 52W High
-33.0%
$164.09 lo$386.33 hi
33.0% below 52W high, ongoing decline
In Stage 4, distance from the 52-week high reflects an ongoing decline, not a discount.
Stage Maturity
Week 1
1w13w26w
Week 1, early Stage 4 decline
How long this stock has been in Stage 4 decline. The longer the downtrend, the more entrenched the selling pressure. No length of decline marks a bottom on its own.
vs 200 DMA
-17.9%
200 DMA: $315.25 · sloping down
In Stage 4, the stock is below its 200-day average, the hallmark of a downtrend. Stage analysis waits for that to reverse before buying.
Rel Volume
0.78x
vs 50-day avg
High volume on down days in Stage 4 confirms institutional selling. Low-volume bounces are typical. They lack real buyers and are easy to mistake for reversals.
Trend Health
↓
Short-term trend rolling over
Two reads of momentum. The arrow shows the direction of the short-term trend: rising (↑ or ↗), flat (→) or rolling over (↓). The ⇈ mark appears when our trend model reads the move as gaining speed on top of the longer trend. Strongest when both agree.
1M
-8.2%
3M
-20.4%
6M
-21.4%
YTD
-9.6%
1Y
+36.3%
Scan Membership
Breakout Watch
Latest: 2024-07-30
3 appearances in last 60 days. First seen: 2023-02-27.
A stock that keeps qualifying week after week does so because its Stage 2 structure keeps holding. Staying power in the scan says more about the trend than any single appearance.
Recent Stage Timeline
2026-10-22S43→4
Wk 1 · Vol 0.78x
2026-10-21S3
Wk 4 · Vol 0.77x
2026-10-20S3
Wk 3 · Vol 1.97x
2026-10-19S3
Wk 3 · Vol 1.94x
2026-10-16S3
Wk 3 · Vol 1.17x
2026-10-15S3
Wk 3 · Vol 1.39x
2026-10-14S3
Wk 3 · Vol 2.17x
2026-10-13S3
Wk 2 · Vol 1.43x
2026-10-12S3
Wk 2 · Vol 0.69x
2026-10-09S3
Wk 2 · Vol 1.18x
2026-10-08S3
Wk 2 · Vol 1.57x
2026-10-07S3
Wk 2 · Vol 1.03x
Moving averages & range
50 DMA
$312.97
200 DMA
$315.25
52W High
$386.33
52W Low
$164.09
5D Low
$241.76
Resistance levels (recent highs)
20d High
$295.51
60d High
$386.33
120d High
$386.33
250d High
$386.33
Next resistance
+14.1%
to 20d High
ROE
-38.9%
Profit margin 0.0%
Dividend Yield
0.00%
P/B 5.4

Praxis Precision Medicines: quick answers

What stage is Praxis Precision Medicines in?

As of Oct 22, 2026, Praxis Precision Medicines (PRAX) is in Stage 4, the downtrend phase. It entered Stage 4 on Oct 22, 2026 and is in its first week there. What the four stages mean

Is Praxis Precision Medicines in an uptrend?

No. Praxis Precision Medicines is in a Stage 4 downtrend. It trades 17.9% below its 200-day average, which is falling.

How far is Praxis Precision Medicines from its 52-week high?

Praxis Precision Medicines closed at $258.92 on Oct 22, 2026, 33.0% below its 52-week high of $386.33. Its 52-week low is $164.09.

How has Praxis Precision Medicines performed over the past year?

As of Oct 22, 2026, Praxis Precision Medicines is up 36.3% over the past year and down 9.6% so far in 2026.

Which sector and industry is Praxis Precision Medicines in?

Praxis Precision Medicines is in the Biotechnology industry, part of the Health Care sector.

About this companyHealth Care· Biotechnology

Praxis Precision Medicines, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance in the United States. The company's platforms include Cerebrum, a small molecule platform for CNS small molecule therapies to develop orally available precision therapies; and Solidus to discover and develop antisense oligonucleotide. It also develops ulixacaltamide, a small molecule inhibitor of T-type calcium channels that in NDA for the treatment of essential tremor; relutrigine, a small molecule, which is in NDA for the treatment of SCN2A- and SCN8A-developmental and epileptic encephalopathies (DEE), as well as in Phase 3 trial for broad DEEs; vormatrigine, a small molecule targeting the hyperexcitable state of sodium-channels in the brain that is in Phase 3 trial for the treatment of adjunctive focal epilepsy, as well as in Phase 2 trial for monotherapy focal epilepsy; and Elsunersen, a clinical-stage ASO designed to selectively decrease SCN2A gene expression, which is in Phase 3 trial for the treatment of SCN2A-DEE. In addition, the company is developing product candidates in pre-clinical trial comprising PRAX-020 to treat KCNT1; PRAX-080 that targets PCDH19 mosaic expression disorders; PRAX-090 for targeting SYNGAP1 loss-of-function; and PRAX-100 that targets SCN2A LoF mutations. It has a cooperation and license agreement with RogCon Inc.; research collaboration, option, and license agreement with Ionis Pharmaceuticals, Inc.; and research collaboration and license agreement to develop an iontophoretic transdermal patch for the delivery of ulixacaltamide. The company was formerly known as EpiPM Therapeutics, Inc. and changed its name to Praxis Precision Medicines, Inc. in October 2016. Praxis Precision Medicines, Inc. was incorporated in 2015 and is headquartered in Boston, Massachusetts.

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All analytics based on EOD data. Data as of 2026-10-22. Past data patterns are not indicative of future results. This page is a data analytics tool only.