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Alnylam Pharmaceuticals, Inc.

Stage 4 · Declining · week 36

As of Oct 22, 2026, Alnylam Pharmaceuticals is in Stage 4, the downtrend phase, now in week 36 (since Feb 11, 2026). It closed at $227.28, 52.8% below its 52-week high and below its 200-day average, which is falling.

Alnylam Pharmaceuticals, Inc. discovers, develops, manufactures, and commercializes therapeutics based on ribonucleic acid interference in the United States, Europe, and internationally. More about the company

$227.28
+0.97% today
$30.4B · Large cap
Market Neutral — Building

Pro read

Pro

Our read

Declining, below its long-term trend

Setup score

—

Momentum

Steady

Edge

—

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Loading price chart…
Stage Cycle Timeline2023-08-16 → 2026-10-22
S4 18w
S4 16w
S2 20w
S2 25w
S4 36w
2023-08-162026-10-22
S1S2S3S4Setup score (0–10, dashed line at 5)
S4 18w → S1 9w → S4 16w → S1 3w → S2 20w → S3 11w → S2 8w → S1 1w → S4 4w → S1 2w → S2 25w → S3 11w → S4 36w current
Total tracked: 165 weeks across 13 stage runs.

ALNY among Biotechnology351st of 591 by relative strength

All 591 →
Stocks in Biotechnology ranked by relative strength, with stage and one-month change
#StockStageRS1M
1GTBPStage 2 · wk 799−22.3%
2IOVAStage 2 · wk 1899+38.8%
3SLSStage 3 · wk 499−1.5%
4MRNAStage 2 · wk 1799+11.3%
5TWSTStage 2 · wk 3999−14.5%
6KODStage 2 · wk 499+172.1%
7ERASStage 3 · wk 599+0.7%
8CLYMStage 3 · wk 399−15.8%
…351ALNYStage 4 · wk 3623−7.8%
vs 52W High
-52.8%
$205.48 lo$481.59 hi
52.8% below 52W high, deep Stage 4 damage
In Stage 4, distance from the 52-week high reflects an ongoing decline, not a discount.
Stage Maturity
Week 36
1w13w26w
Week 36, extended decline
How long this stock has been in Stage 4 decline. The longer the downtrend, the more entrenched the selling pressure. No length of decline marks a bottom on its own.
vs 200 DMA
-21.9%
200 DMA: $290.87 · sloping down
In Stage 4, the stock is below its 200-day average, the hallmark of a downtrend. Stage analysis waits for that to reverse before buying.
Rel Volume
1.50x
vs 50-day avg
High volume on down days in Stage 4 confirms institutional selling. Low-volume bounces are typical. They lack real buyers and are easy to mistake for reversals.
Trend Health
↓
Short-term trend rolling over
Two reads of momentum. The arrow shows the direction of the short-term trend: rising (↑ or ↗), flat (→) or rolling over (↓). The ⇈ mark appears when our trend model reads the move as gaining speed on top of the longer trend. Strongest when both agree.
1M
-7.8%
3M
-16.4%
6M
-27.6%
YTD
-43.2%
1Y
-52.1%
Scan Membership
Breakout Watch
Latest: 2025-05-29
10 appearances in last 60 days. First seen: 2019-04-29.
A stock that keeps qualifying week after week does so because its Stage 2 structure keeps holding. Staying power in the scan says more about the trend than any single appearance.
Recent Stage Timeline
2026-10-22S4
Wk 36 · Vol 1.50x
2026-10-21S4
Wk 35 · Vol 0.78x
2026-10-20S4
Wk 35 · Vol 1.02x
2026-10-19S4
Wk 35 · Vol 0.90x
2026-10-16S4
Wk 35 · Vol 0.93x
2026-10-15S4
Wk 35 · Vol 0.82x
2026-10-14S4
Wk 34 · Vol 0.70x
2026-10-13S4
Wk 34 · Vol 0.69x
2026-10-12S4
Wk 34 · Vol 0.54x
2026-10-09S4
Wk 34 · Vol 0.51x
2026-10-08S4
Wk 34 · Vol 0.95x
2026-10-07S4
Wk 33 · Vol 0.57x
Moving averages & range
50 DMA
$239.12
200 DMA
$290.87
52W High
$481.59
52W Low
$205.48
5D Low
$225.10
Resistance levels (recent highs)
20d High
$255.96
60d High
$267.40
120d High
$323.50
250d High
$481.59
Next resistance
+12.6%
to 20d High
P/E (TTM)
38.3
Forward 18.4
ROE
+96.6%
Profit margin +16.1%
Dividend Yield
0.00%
P/B 22.4

Alnylam Pharmaceuticals: quick answers

What stage is Alnylam Pharmaceuticals in?

As of Oct 22, 2026, Alnylam Pharmaceuticals (ALNY) is in Stage 4, the downtrend phase. It entered Stage 4 on Feb 11, 2026 and is in week 36. What the four stages mean

Is Alnylam Pharmaceuticals in an uptrend?

No. Alnylam Pharmaceuticals is in a Stage 4 downtrend. It trades 21.9% below its 200-day average, which is falling.

How far is Alnylam Pharmaceuticals from its 52-week high?

Alnylam Pharmaceuticals closed at $227.28 on Oct 22, 2026, 52.8% below its 52-week high of $481.59. Its 52-week low is $205.48.

How has Alnylam Pharmaceuticals performed over the past year?

As of Oct 22, 2026, Alnylam Pharmaceuticals is down 52.1% over the past year and down 43.2% so far in 2026.

Which sector and industry is Alnylam Pharmaceuticals in?

Alnylam Pharmaceuticals is in the Biotechnology industry, part of the Health Care sector.

About this companyHealth Care· Biotechnology

Alnylam Pharmaceuticals, Inc. discovers, develops, manufactures, and commercializes therapeutics based on ribonucleic acid interference in the United States, Europe, and internationally. The company offers ONPATTRO for hereditary transthyretin-mediated (hATTR) amyloidosis; AMVUTTRA for ATTR and hATTR amyloidosis; Leqvio for hypercholesterolemia; Qfitlia for hemophilia A or B; GIVLAARI for acute hepatic porphyria; and OXLUMO for primary hyperoxaluria type 1. It also develops a range of products in Phase 3 trial, such as Nucresiran for ATTR amyloidosis; Zilebesiran for hypertension; Cemdisiran for myasthenia gravis, paroxysmal nocturnal hemoglobinuria, and geographic atrophy; and Elebsiran for hepatitis D virus infections. In addition, the company is developing various products in Phase 2 trial, including Rapirosiran for metabolic dysfunction-associated steatohepatitis; ALN-ANG3 for diabetic kidney disease; ALN-4324 for type 2 diabetes mellitus; Mivelsiran for cerebral amyloid angiopathy, as well as in Phase 1 trial for Alzheimer's disease; and ALN-6400 for bleeding disorders. Further, it develops a range of products in Phase 1 trial, such as ALN-2232 for obesity and weight management; ALN-PNP for non-alcoholic fatty liver disease; ALN-APOC3 for dyslipidemia; ALN-CIDEB for metabolic dysfunction-associated steatohepatitis; ALN-HTT02 for Huntington's disease; ALN-5288 for Alzheimer's disease; ALN-SOD for SOD1 amyotrophic lateral sclerosis; ALN-SNCA for Parkinson's disease; AG-236 for polycythemia vera; ALN-CFB for paroxysmal nocturnal hemoglobinuria; ALN-BCAT for hepatocellular carcinoma; and ALN-4285, ALN-4915, and ALN-F1202 for healthy volunteers. The company has collaborations with Regeneron Pharmaceuticals, Inc.; Roche Holding AG; Sanofi S.A.; Novartis AG; PeptiDream, Inc; Dicerna Pharmaceuticals, Inc.; and Ionis Pharmaceuticals, Inc. Alnylam Pharmaceuticals, Inc. was founded in 2002 and is headquartered in Cambridge, Massachusetts.

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All analytics based on EOD data. Data as of 2026-10-22. Past data patterns are not indicative of future results. This page is a data analytics tool only.