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Pyxis Oncology, Inc.

Stage 3 · Topping · week 2

As of Oct 22, 2026, Pyxis Oncology is in Stage 3, the topping phase, now in week 2 (since Oct 14, 2026). It closed at $1.71, 68.0% below its 52-week high and below its 200-day average, which is falling.

Pyxis Oncology, Inc., a clinical stage company, engages in the development of therapeutics to treat solid tumors. More about the company

$1.71
-4.47% today
$204M · Micro cap
Market Neutral — Building

Pro read

Pro

Our read

Topping: the uptrend is tiring

Setup score

—

Momentum

Steady

Edge

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Is PYXS early, or has it already run? Pro answers that for every US stock we cover, after every close.

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Stage Cycle Timeline2023-08-16 → 2026-10-22
S4 16w
S4 26w
S2 15w
S1 14w
2023-08-162026-10-22
S1S2S3S4Setup score (0–10, dashed line at 5)
S3 4w → S4 16w → S1 4w → S2 13w → S3 13w → S4 5w → S1 5w → S4 3w → S1 3w → S4 26w → S1 10w → S4 4w → S1 2w → S2 15w → S3 6w → S4 7w → S1 1w → S4 3w → S1 14w → S2 10w → S3 1w current
Total tracked: 165 weeks across 21 stage runs.

PYXS among Biotechnology367th of 591 by relative strength

All 591 →
Stocks in Biotechnology ranked by relative strength, with stage and one-month change
#StockStageRS1M
1GTBPStage 2 · wk 799−22.3%
2IOVAStage 2 · wk 1899+38.8%
3SLSStage 3 · wk 499−1.5%
4MRNAStage 2 · wk 1799+11.3%
5TWSTStage 2 · wk 3999−14.5%
6KODStage 2 · wk 499+172.1%
7ERASStage 3 · wk 599+0.7%
8CLYMStage 3 · wk 399−15.8%
…367PYXSStage 3 · wk 222−46.9%
vs 52W High
-68.0%
$1.06 lo$5.34 hi
68.0% below 52W high, weakening from peak
The stock is rolling over from its 52-week high. In Stage 3 distribution, new long positions carry high risk.
Stage Maturity
Week 2
1w13w26w
Week 2, early distribution
How long this stock has been in Stage 3 distribution. Longer tops often precede deeper Stage 4 declines.
vs 200 DMA
-20.7%
200 DMA: $2.16 · sloping down
Stock is losing its 200 DMA. Once lost, it confirms Stage 4 risk. This is a major red flag for existing holders.
Rel Volume
0.51x
vs 50-day avg
Volume spikes on down days during Stage 3 signal distribution, with institutions exiting. Stage analysis reads that as a warning against new long positions.
Trend Health
↓
Short-term trend rolling over
Two reads of momentum. The arrow shows the direction of the short-term trend: rising (↑ or ↗), flat (→) or rolling over (↓). The ⇈ mark appears when our trend model reads the move as gaining speed on top of the longer trend. Strongest when both agree.
1M
-46.9%
3M
-34.5%
6M
+0.0%
YTD
+48.7%
1Y
-52.2%
Scan Membership
Breakout Watch
Latest: 2024-02-09
2 appearances in last 60 days. First seen: 2023-03-30.
A stock that keeps qualifying week after week does so because its Stage 2 structure keeps holding. Staying power in the scan says more about the trend than any single appearance.
Recent Stage Timeline
2026-10-22S3
Wk 2 · Vol 0.51x
2026-10-21S3
Wk 2 · Vol 0.38x
2026-10-20S3
Wk 1 · Vol 0.84x
2026-10-19S3
Wk 1 · Vol 0.77x
2026-10-16S3
Wk 1 · Vol 0.68x
2026-10-15S3
Wk 1 · Vol 0.41x
2026-10-14S32→3
Wk 1 · Vol 1.18x
2026-10-13S2
Wk 10 · Vol 0.68x
2026-10-12S2
Wk 10 · Vol 0.38x
2026-10-09S2
Wk 10 · Vol 0.72x
2026-10-08S2
Wk 9 · Vol 0.83x
2026-10-07S2
Wk 9 · Vol 0.71x
Moving averages & range
50 DMA
$2.81
200 DMA
$2.16
52W High
$5.34
52W Low
$1.06
5D Low
$1.68
Resistance levels (recent highs)
20d High
$2.90
60d High
$3.89
120d High
$3.89
250d High
$5.34
Next resistance
+69.6%
to 20d High
ROE
-179.1%
Profit margin 0.0%
Dividend Yield
0.00%
P/B 9.5

Pyxis Oncology: quick answers

What stage is Pyxis Oncology in?

As of Oct 22, 2026, Pyxis Oncology (PYXS) is in Stage 3, the topping phase. It entered Stage 3 on Oct 14, 2026 and is in week 2. What the four stages mean

Is Pyxis Oncology in an uptrend?

Its uptrend has stalled. Pyxis Oncology is in Stage 3, the topping phase that follows an advance. It trades 20.7% below its 200-day average, which is falling.

How far is Pyxis Oncology from its 52-week high?

Pyxis Oncology closed at $1.71 on Oct 22, 2026, 68.0% below its 52-week high of $5.34. Its 52-week low is $1.06.

How has Pyxis Oncology performed over the past year?

As of Oct 22, 2026, Pyxis Oncology is down 52.2% over the past year and up 48.7% so far in 2026.

Which sector and industry is Pyxis Oncology in?

Pyxis Oncology is in the Biotechnology industry, part of the Health Care sector.

About this companyHealth Care· Biotechnology

Pyxis Oncology, Inc., a clinical stage company, engages in the development of therapeutics to treat solid tumors. Its lead antibody-drug conjugates (ADC) product candidate is PYX-201, an investigational novel ADC consisting of human immunoglobulin G1 (IgG1), which is in Phase 1 clinical trial to treat patients with relapsed or refractory solid tumors; PYX-102, an investigational immunotherapeutic targeting KLRG1, an inhibitory receptor on T cells and NK cells, with potential for use as monotherapy or in combination treatments; and lead immuno-oncology (IO) product candidate is PYX-106, an investigational fully human IgG1 Siglec-15-targeting antibody that is in Phase 1 clinical trial to treat patients with advanced solid tumors. The company is also developing PYX-107, a CD40 agonist with demonstrated anti-cancer activity in patients with several cancer indications, which is in Phase 2 clinical trial for the treatment of tumors, such as soft tissue sarcomas, esophageal and gastroesophageal junction, cancers, and pancreatic ductal adenocarcinoma. It has an in-license agreement with Pfizer Inc. to develop and commercialize ADC product candidates, including micvotabart pelidotin and PYX-203, and other ADC product candidates directed to the licensed targets; and Biosion USA, Inc. for development, manufacture, and commercialization of PYX-106, an IO product candidate. Pyxis Oncology, Inc. was incorporated in 2018 and is headquartered in Boston, Massachusetts.

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All analytics based on EOD data. Data as of 2026-10-22. Past data patterns are not indicative of future results. This page is a data analytics tool only.