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Prothena Corporation plc

Stage 4 · Declining · week 5

As of Oct 22, 2026, Prothena is in Stage 4, the downtrend phase, now in week 5 (since Sep 21, 2026). It closed at $8.25, 28.3% below its 52-week high and below its 200-day average, which is falling.

Prothena Corporation plc, a late-stage clinical biotechnology company, focuses on discovery and development of novel therapies to treat diseases caused by protein dysregulation. More about the company

$8.25
+2.74% today
$424M · Small cap
Market Neutral — Building

Pro read

Pro

Our read

Declining, below its long-term trend

Setup score

—

Momentum

Steady

Edge

—

Is PRTA early, or has it already run? Pro answers that for every US stock we cover, after every close.

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Stage Cycle Timeline2023-08-16 → 2026-10-22
S4 43w
S4 22w
S4 20w
S3 14w
2023-08-162026-10-22
S1S2S3S4Setup score (0–10, dashed line at 5)
S3 5w → S4 43w → S1 4w → S4 3w → S1 2w → S4 22w → S1 3w → S4 20w → S1 13w → S2 8w → S3 14w → S2 9w → S3 3w → S4 8w → S1 2w → S4 5w current
Total tracked: 164 weeks across 16 stage runs.

PRTA among Biotechnology242nd of 591 by relative strength

All 591 →
Stocks in Biotechnology ranked by relative strength, with stage and one-month change
#StockStageRS1M
1GTBPStage 2 · wk 799−22.3%
2IOVAStage 2 · wk 1899+38.8%
3SLSStage 3 · wk 499−1.5%
4MRNAStage 2 · wk 1799+11.3%
5TWSTStage 2 · wk 3999−14.5%
6KODStage 2 · wk 499+172.1%
7ERASStage 3 · wk 599+0.7%
8CLYMStage 3 · wk 399−15.8%
…242PRTAStage 4 · wk 540−5.0%
vs 52W High
-28.3%
$7.91 lo$11.51 hi
28.3% below 52W high, ongoing decline
In Stage 4, distance from the 52-week high reflects an ongoing decline, not a discount.
Stage Maturity
Week 5
1w13w26w
Week 5, early Stage 4 decline
How long this stock has been in Stage 4 decline. The longer the downtrend, the more entrenched the selling pressure. No length of decline marks a bottom on its own.
vs 200 DMA
-10.8%
200 DMA: $9.25 · sloping down
In Stage 4, the stock is below its 200-day average, the hallmark of a downtrend. Stage analysis waits for that to reverse before buying.
Rel Volume
0.83x
vs 50-day avg
High volume on down days in Stage 4 confirms institutional selling. Low-volume bounces are typical. They lack real buyers and are easy to mistake for reversals.
Trend Health
↓
Short-term trend rolling over
Two reads of momentum. The arrow shows the direction of the short-term trend: rising (↑ or ↗), flat (→) or rolling over (↓). The ⇈ mark appears when our trend model reads the move as gaining speed on top of the longer trend. Strongest when both agree.
1M
-5.0%
3M
-5.7%
6M
-23.1%
YTD
-10.3%
1Y
-19.2%
Scan Membership
Breakout Watch
Latest: 2023-05-05
6 appearances in last 60 days. First seen: 2019-12-16.
A stock that keeps qualifying week after week does so because its Stage 2 structure keeps holding. Staying power in the scan says more about the trend than any single appearance.
Recent Stage Timeline
2026-10-22S4
Wk 5 · Vol 0.83x
2026-10-21S4
Wk 5 · Vol 0.88x
2026-10-20S4
Wk 5 · Vol 1.14x
2026-10-19S4
Wk 5 · Vol 0.77x
2026-10-16S4
Wk 4 · Vol 1.45x
2026-10-15S4
Wk 4 · Vol 0.77x
2026-10-14S4
Wk 4 · Vol 1.35x
2026-10-13S4
Wk 4 · Vol 1.25x
2026-10-12S4
Wk 4 · Vol 1.06x
2026-10-09S4
Wk 3 · Vol 2.06x
2026-10-08S4
Wk 3 · Vol 1.42x
2026-10-07S4
Wk 3 · Vol 1.52x
Moving averages & range
50 DMA
$8.80
200 DMA
$9.25
52W High
$11.51
52W Low
$7.91
5D Low
$8.03
Resistance levels (recent highs)
20d High
$8.84
60d High
$9.82
120d High
$11.19
250d High
$11.51
Next resistance
+7.2%
to 20d High
ROE
-14.4%
Profit margin -80.7%
Dividend Yield
0.00%
P/B 1.5

Prothena: quick answers

What stage is Prothena in?

As of Oct 22, 2026, Prothena (PRTA) is in Stage 4, the downtrend phase. It entered Stage 4 on Sep 21, 2026 and is in week 5. What the four stages mean

Is Prothena in an uptrend?

No. Prothena is in a Stage 4 downtrend. It trades 10.8% below its 200-day average, which is falling.

How far is Prothena from its 52-week high?

Prothena closed at $8.25 on Oct 22, 2026, 28.3% below its 52-week high of $11.51. Its 52-week low is $7.91.

How has Prothena performed over the past year?

As of Oct 22, 2026, Prothena is down 19.2% over the past year and down 10.3% so far in 2026.

Which sector and industry is Prothena in?

Prothena is in the Biotechnology industry, part of the Health Care sector.

About this companyHealth Care· Biotechnology

Prothena Corporation plc, a late-stage clinical biotechnology company, focuses on discovery and development of novel therapies to treat diseases caused by protein dysregulation. Its product pipeline includes Prasinezumab, an investigational humanized monoclonal antibody which is in Phase 3 clinical trial for the treatment of parkinson's disease and other synucleinopathies. The company also develops Coramitug, an investigational antibody, which is in Phase 3 clinical trial for the treatment of transthyretin amyloidosis; BMS-986446, an anti-tau antibody which is in Phase 2 clinical trial to treat Alzheimer's disease; PRX019, an investigational antibody which is in Phase 1 clinical trial for the treatment of neurodegenerative diseases; and PRX123, a Dual Aß-Tau Vaccine, which is in preclinical trial for treating Alzheimer's disease. In addition, it develops discovery- and late-preclinical-stage programs include TDP-43 CYTOPE for the treatment of amyotrophic lateral sclerosis; PRX012, a next-generation anti-Aß antibody which is in phase 1 clinical trial to treat Alzheimer's disease; and PRX012-TfR, a preclinical program for the treatment of Alzheimer's disease. It has a license, development, and commercialization agreement with F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. to develop and commercialize antibodies that target a-synuclein, including prasinezumab; and master collaboration agreement with Bristol Myers Squibb to develop and commercialize antibodies targeting tau, TDP-43. Prothena Corporation plc was incorporated in 2012 and is based in Dublin, Ireland.

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All analytics based on EOD data. Data as of 2026-10-22. Past data patterns are not indicative of future results. This page is a data analytics tool only.