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Bicycle Therapeutics plc

Stage 4 · Declining · week 5

As of Oct 22, 2026, Bicycle Therapeutics is in Stage 4, the downtrend phase, now in week 5 (since Sep 18, 2026). It closed at $3.64, 58.4% below its 52-week high and below its 200-day average, which is falling.

Bicycle Therapeutics plc, a clinical-stage pharmaceutical company, develops a class of medicines for diseases that are underserved by existing therapeutics in the United States and the United Kingdom. More about the company

$3.64
+4.00% today
$255M · Micro cap
Market Neutral — Building

Pro read

Pro

Our read

Declining, below its long-term trend

Setup score

—

Momentum

Steady

Edge

—

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Stage Cycle Timeline2023-08-16 → 2026-10-22
S4 22w
S2 16w
S4 30w
S4 14w
S4 42w
2023-08-162026-10-22
S1S2S3S4Setup score (0–10, dashed line at 5)
S4 22w → S1 8w → S2 9w → S3 11w → S2 16w → S3 2w → S4 30w → S1 2w → S4 14w → S1 4w → S4 42w → S1 1w → S4 5w current
Total tracked: 165 weeks across 13 stage runs.

BCYC among Biotechnology375th of 591 by relative strength

All 591 →
Stocks in Biotechnology ranked by relative strength, with stage and one-month change
#StockStageRS1M
1GTBPStage 2 · wk 799−22.3%
2IOVAStage 2 · wk 1899+38.8%
3SLSStage 3 · wk 499−1.5%
4MRNAStage 2 · wk 1799+11.3%
5TWSTStage 2 · wk 3999−14.5%
6KODStage 2 · wk 499+172.1%
7ERASStage 3 · wk 599+0.7%
8CLYMStage 3 · wk 399−15.8%
…375BCYCStage 4 · wk 521+1.1%
vs 52W High
-58.4%
$3.38 lo$8.76 hi
58.4% below 52W high, deep Stage 4 damage
In Stage 4, distance from the 52-week high reflects an ongoing decline, not a discount.
Stage Maturity
Week 5
1w13w26w
Week 5, early Stage 4 decline
How long this stock has been in Stage 4 decline. The longer the downtrend, the more entrenched the selling pressure. No length of decline marks a bottom on its own.
vs 200 DMA
-21.7%
200 DMA: $4.65 · sloping down
In Stage 4, the stock is below its 200-day average, the hallmark of a downtrend. Stage analysis waits for that to reverse before buying.
Rel Volume
0.63x
vs 50-day avg
High volume on down days in Stage 4 confirms institutional selling. Low-volume bounces are typical. They lack real buyers and are easy to mistake for reversals.
Trend Health
↓
Short-term trend rolling over
Two reads of momentum. The arrow shows the direction of the short-term trend: rising (↑ or ↗), flat (→) or rolling over (↓). The ⇈ mark appears when our trend model reads the move as gaining speed on top of the longer trend. Strongest when both agree.
1M
+1.1%
3M
-5.9%
6M
-24.9%
YTD
-45.5%
1Y
-56.1%
Scan Membership
Breakout Watch
Latest: 2024-08-05
6 appearances in last 60 days. First seen: 2020-03-09.
A stock that keeps qualifying week after week does so because its Stage 2 structure keeps holding. Staying power in the scan says more about the trend than any single appearance.
Recent Stage Timeline
2026-10-22S4
Wk 5 · Vol 0.63x
2026-10-21S4
Wk 5 · Vol 0.91x
2026-10-20S4
Wk 5 · Vol 1.15x
2026-10-19S4
Wk 5 · Vol 1.66x
2026-10-16S4
Wk 5 · Vol 1.38x
2026-10-15S4
Wk 4 · Vol 1.01x
2026-10-14S4
Wk 4 · Vol 1.09x
2026-10-13S4
Wk 4 · Vol 1.14x
2026-10-12S4
Wk 4 · Vol 0.58x
2026-10-09S4
Wk 4 · Vol 0.74x
2026-10-08S4
Wk 3 · Vol 0.83x
2026-10-07S4
Wk 3 · Vol 1.17x
Moving averages & range
50 DMA
$3.87
200 DMA
$4.65
52W High
$8.76
52W Low
$3.38
5D Low
$3.46
Resistance levels (recent highs)
20d High
$4.01
60d High
$4.39
120d High
$5.15
250d High
$8.76
Next resistance
+10.2%
to 20d High
ROE
-32.3%
Profit margin 0.0%
Dividend Yield
0.00%
P/B 0.5

Bicycle Therapeutics: quick answers

What stage is Bicycle Therapeutics in?

As of Oct 22, 2026, Bicycle Therapeutics (BCYC) is in Stage 4, the downtrend phase. It entered Stage 4 on Sep 18, 2026 and is in week 5. What the four stages mean

Is Bicycle Therapeutics in an uptrend?

No. Bicycle Therapeutics is in a Stage 4 downtrend. It trades 21.7% below its 200-day average, which is falling.

How far is Bicycle Therapeutics from its 52-week high?

Bicycle Therapeutics closed at $3.64 on Oct 22, 2026, 58.4% below its 52-week high of $8.76. Its 52-week low is $3.38.

How has Bicycle Therapeutics performed over the past year?

As of Oct 22, 2026, Bicycle Therapeutics is down 56.1% over the past year and down 45.5% so far in 2026.

Which sector and industry is Bicycle Therapeutics in?

Bicycle Therapeutics is in the Biotechnology industry, part of the Health Care sector.

About this companyHealth Care· Biotechnology

Bicycle Therapeutics plc, a clinical-stage pharmaceutical company, develops a class of medicines for diseases that are underserved by existing therapeutics in the United States and the United Kingdom. The company's products pipeline include zelenectide pevedotin, a bicycle toxin conjugate (BTC), which is in phase II clinical trials for the treatment of high nectin-4 expressing tumors; nuzefatide pevedotin (EphA2), a BTC that is in phase I/II clinical trials to treat Ephrin type A receptor 2 expressing tumor; BT7480, a Bicycle tumor-targeted immune cell agonist molecule, which is in phase I/II targeting nectin-4 and agonizing CD137; and BT1702, a theranostic BRC molecule targeting MT1-MMP for which IND-enabling activities are ongoing. In addition, it develops Novel CNS targets, which is in preclinical trial targeting CNS disease; Novel neuromuscular targets, which is in preclinical trial targeting neuromuscular disease; and programs that are in preclinical trial targeting radiopharmaceutical. Further, the company collaborates with biopharmaceutical companies and organizations to develop programs in therapeutic areas. It has collaboration and license agreement with Bayer Consumer Care AG; Novartis Pharma AG; Ionis Pharmaceuticals, Inc.; Genentech, Inc; and AstraZeneca AB. Bicycle Therapeutics plc was incorporated in 2009 and is headquartered in Cambridge, the United Kingdom.

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All analytics based on EOD data. Data as of 2026-10-22. Past data patterns are not indicative of future results. This page is a data analytics tool only.